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Concentrations of azithromycin in human tonsillar tissue
G Foulds1, K H Chan, J T Johnson
1Central Research Division, Pfizer Inc., Groton, CT 06340.
Summary
High azithromycin concentrations were found in tonsil tissue after oral administration. This suggests a short, once-daily azithromycin regimen may effectively treat tonsillo-pharyngitis.
Area of Science:
- Pharmacology
- Infectious Diseases
Background:
- Tonsillo-pharyngitis is a common infection.
- Antibiotic efficacy depends on drug concentration at the infection site.
Purpose of the Study:
- To determine azithromycin concentrations in tonsillar tissue after oral administration.
- To evaluate the potential for azithromycin in treating tonsillo-pharyngitis.
Main Methods:
- Patients received oral azithromycin (500 mg).
- Tonsil tissue and serum samples were collected at various time points.
- Azithromycin concentrations were measured using assays.
Main Results:
- Mean tonsillar azithromycin concentrations were significantly higher than serum concentrations (ratio > 150-fold).
- High concentrations persisted for up to 7.5 days after the last dose.
- Apparent half-life in tonsil tissue was 76 hours.
Conclusions:
- Oral azithromycin achieves substantial concentrations in tonsillar tissue.
- A short, once-daily azithromycin regimen may be effective for tonsillo-pharyngitis treatment.