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Gynaecological tissue levels of azithromycin
1Department of Gynaecology and Obstetrics, Centrallasarettet, Norrköping, Sweden.
Summary
A single 500 mg oral dose of azithromycin provides high, sustained concentrations in gynecological tissue for up to 96 hours. This antibiotic was well-tolerated, showing potential for gynecological infections.
Area of Science:
- Pharmacokinetics
- Gynecology
- Infectious Diseases
Background:
- Azithromycin is a widely used antibiotic.
- Understanding its tissue distribution is crucial for optimizing treatment regimens.
Purpose of the Study:
- To compare azithromycin concentrations in plasma, urine, peritoneal fluid, and gynecological tissue.
- To evaluate the pharmacokinetic profile of a single 500 mg oral dose administered at different pre-surgical time points.
Main Methods:
- Open study involving 20 patients undergoing elective gynecological surgery.
- Single oral dose of 500 mg azithromycin administered 24, 48, 72, or 96 hours pre-surgery.
- Analysis of drug concentrations in biological samples and tissue.
Main Results:
- High azithromycin concentrations were maintained in gynecological tissue up to 96 hours post-administration.
- Tissue and peritoneal fluid concentrations significantly exceeded plasma levels.
- The estimated half-life of azithromycin was approximately 67 hours.
- Urinary excretion was 6% over seven days.
Conclusions:
- A single 500 mg oral dose of azithromycin achieves prolonged and elevated levels in gynecological tissues.
- This sustained tissue concentration suggests potential efficacy for treating gynecological infections.
- Azithromycin was well-tolerated with no observed side effects.