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Updated: Aug 8, 2026
09:46
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Clinical characteristics of cortical multiple sclerosis
1Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. mojtaba@fmrib.ox.ac.uk
Journal of the Neurological Sciences
|April 22, 2006
Summary
Cortical multiple sclerosis is a variant characterized by brain cortex issues, leading to neurobehavioral symptoms like depression and amnesia. Further research supports this concept and aids in identifying affected patients.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Multiple sclerosis (MS) neurobehavioral and cognitive complications are not fully understood.
- Previous work suggested a variant,
- cortical multiple sclerosis
- , characterized by cortical pathology and distinct neurobehavioral symptoms.
Purpose of the Study:
- To detail the clinical characteristics of cortical multiple sclerosis.
- To present an approach for detecting patients with this MS variant.
Main Methods:
- Review of neuroimaging and neuropathological findings.
- Observation and analysis of patients with neurobehavioral symptoms suggestive of cortical dysfunction.
- Synthesis of existing case reports and pathological studies.
Main Results:
- Cortical multiple sclerosis presents with predominant or exclusive cortical pathology.
- Symptoms include depression, amnesia, and specific cortical syndromes.
- Further evidence supports the concept of cortical multiple sclerosis since its initial proposal.
Conclusions:
- Cortical multiple sclerosis is a recognized variant of MS.
- Clinical characteristics and detection methods for this variant have been refined.
- Understanding cortical MS is crucial for comprehensive patient care.
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