Related Experiment Video
Updated: Aug 9, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction
Marco Rovaris1, Giancarlo Comi, Massimo Filippi
1Department of Neurology, Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy. rovaris.marco@hsr.it
Abstract:
Studies with conventional magnetic resonance imaging (MRI) indicate that cognitive impairment in multiple sclerosis (MS) patients is not fully explained by the burden of T2-visible lesions in the brain. Other non-conventional MRI techniques with increased specificity to the more destructive aspects of MS pathology, such as magnetization transfer MRI, diffusion-weighted MRI and proton magnetic resonance spectroscopy, have recently been applied to MS cognitive studies. The results suggest that the presence and extent of "occult" MS pathological features in the normal-appearing brain tissue and the location of lesions in eloquent sites play a central role in the pathogenesis of MS neuropsychological impairment.
Related Concept Videos
Dementia l: Introduction
Multiple Sclerosis l: Introduction
Alzheimer Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction

