IL-6 and CCL2 levels in CSF are associated with the clinical course of MS: implications for their possible
C Malmeström1, B A Andersson, S Haghighi
1Department of Neurology, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Göteborg University, S-413 45 Göteborg, Sweden. clas.malmestrom@neuro.gu.se
Abstract:
Biological markers would provide valuable tools for tracking disease activity, immunopathological processes or therapeutic efficacy in MS. In this study we analysed a panel of Th(1)/Th(2) cytokines and the chemokine CCL2 in serum and CSF from MS patients and healthy controls. Increased levels of IL-6 (p<0.05) and decreased levels of CCL2 (p<0.001), with the lowest levels during acute relapses, was found in CSF from patients with relapsing-remitting MS. CSF levels of CCL2 correlated with indices for intrathecal IgG production and the CSF level of the neurofilament light protein, a marker for axonal damage, indicating a immunopathogenic role for CCL2.
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