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Impaired gastric myolectrical activity in patients with cystic fibrosis
Lea Bentur1, Bayan Hino, Raanan Shamir
1Pediatric Pulmonary Unit, Meyer Children's Hospital of Haifa, Rambam Medical Center, POB 9602, Haifa 31096, Israel. l_bentur@rambam.health.go.il <l_bentur@rambam.health.go.il>
Background:
Cystic fibrosis (CF) is frequently associated with gastrointestinal complaints that can be due to gastrointestinal dysmotility. Electrogastrography (EGG) is an attractive, non-invasive procedure to assess gastric electric activity. The aims of our study were to investigate EGG abnormalities in pancreatic sufficient and pancreatic insufficient CF patients, and to examine whether EGG correlates with gastric emptying as assessed by scintigraphy.
Methods:
EGG was performed in 23 CF patients (12 pancreatic sufficient patients, 11 pancreatic insuffficient) by using cutaneous recording pre- and postprandialy. Pre- and postpostprandial EGG indexes were compared to 19 healthy control patients. Gastric emptying was assessed simultaneously by gastric scintigraphy in 11 of the 23 CF patients. Six patients underwent a repeated scintigraphy recording following a month of treatment with cisapride.
Results:
Abnormal patterns of EGG were found in 78.3% of CF patients compared to 31.3% of controls during fasting (p
Conclusions:
Our results suggest that EGG abnormalities are frequently found in CF patients. The similar rate of EGG and gastric scintigraphy abnormalities suggests that EGG may be a useful clinical tool in CF patients.
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