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Related Experiment Videos

[HIF-1 activation during tumor progression: implications and consequences].

Marie-Claude Lauzier1, Maude D Michaud, Marc-André C Déry

  • 1Centre de recherche de l'Hôtel-Dieu de Québec, Département de médecine, Université Laval, 10 rue McMahon, QC, Canada G1R 2J6.

Bulletin Du Cancer
|April 22, 2006
PubMed
Summary
This summary is machine-generated.

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Hypoxia-inducible factor 1 (HIF-1) controls over 70 genes during hypoxic stress. This review explores HIF-1

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cellular Signaling

Context:

  • Hypoxia-inducible factor 1 (HIF-1) is a transcription factor regulating gene expression under hypoxic stress.
  • HIF-1 activity is modulated by the HIF-1alpha subunit, whose stability is influenced by post-translational modifications.
  • Active HIF-1 complexes form in many human cancers due to both hypoxic and non-hypoxic stimuli.

Purpose:

  • To review the hypoxic and non-hypoxic stimuli that activate HIF-1.
  • To elucidate the precise implications of HIF-1 activation in tumor progression.
  • To highlight recent advancements in molecular and cellular signaling pathways upstream and downstream of HIF-1.

Summary:

  • HIF-1 regulates over 70 genes involved in cancer progression, including angiogenesis, metabolic shifts to anaerobic glycolysis, and mechanisms controlling cell survival, proliferation, and apoptosis.

Related Experiment Videos

  • The review focuses on stimuli leading to HIF-1 activation and its role in tumor processes.
  • Recent developments in signaling pathways influencing HIF-1 are discussed.

    • Impact:

    • Provides a comprehensive overview of HIF-1's role in cancer, aiding researchers in understanding tumor biology.
    • Highlights the complex interplay of signaling pathways involved in HIF-1 activation and its downstream effects.
    • Offers insights into potential therapeutic targets by detailing HIF-1's involvement in critical cancer processes.