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Volume measurement by CARTO compared with cardiac magnetic resonance

F Grothues1, O Wolfram, C Fantoni

  • 1Department of Cardiology, Otto-von-Guericke-University Leipziger Strasse 44, D-39120 Magdeburg, Germany. frank.grothues@medizin.uni-magdeburg.de

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|April 22, 2006
PubMed

Insights

Cardiac magnetic resonance (CMR) and CARTO electrophysiological mapping show good correlation for ventricular volumes in heart failure patients. However, the methods are not interchangeable for clinical use, especially for right ventricular volumes.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Electrophysiology

Background:

  • The CARTO electrophysiological mapping system is validated for ventricular volume assessment in non-human models.
  • Cardiac magnetic resonance (CMR) is the gold standard for non-invasive ventricular volume quantification.
  • No direct comparison between CARTO and CMR for ventricular volumes in humans existed.

Purpose of the Study:

  • To compare CARTO electrophysiological mapping system-derived ventricular volumes with CMR in heart failure patients.
  • To assess the correlation and interchangeability of these two imaging modalities for volumetric analysis.

Main Methods:

  • 34 heart failure patients (NYHA class III/IV) underwent both CARTO mapping and CMR for ventricular volume measurements.
  • Left ventricular (LV) and right ventricular (RV) end-diastolic volumes (EDV) were measured using both techniques.
  • Statistical analysis included correlation and Bland-Altman analysis to assess agreement.

Main Results:

  • Mean LV end-diastolic volumes were comparable between CMR and CARTO (P = NS).
  • CARTO system measured significantly larger RV end-diastolic volumes compared to CMR (P < 0.01).
  • A good correlation was observed for both chambers, but Bland-Altman analysis indicated non-interchangeability; differences were influenced by mapping point density.

Conclusions:

  • While CARTO and CMR show good correlation for LVEDV and RVEDV in heart failure patients, their clinical interchangeability is questionable.
  • The number of acquired mapping points impacts measurement accuracy, suggesting potential limitations for CARTO in precise volumetric assessment.
  • Further research may be needed to refine CARTO protocols for improved volumetric accuracy and interchangeability with CMR.
Abstract

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