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Updated: Aug 9, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells

Published on: March 9, 2012

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

Qian Yang1, Ken Inoki, Eunjung Kim

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Proceedings of the National Academy of Sciences of the United States of America
|April 22, 2006
PubMed
Summary

The Ras homology enriched in brain (Rheb) small GTPase inhibits TORC2 activity, potentially via a feedback loop involving TORC1 and S6K. Tuberous sclerosis complex 1/2 (TSC1/2) also differentially affects TORC1 and TORC2.

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