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Relation between insulin resistance and hematological parameters in a Brazilian sample
Vivian C M Ellinger1, Ludmila T Carlini, Rodrigo O Moreira
1Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, RJ. vivianellinger@openlink.com.br
Arquivos Brasileiros De Endocrinologia E Metabologia
|April 22, 2006
Summary
Insulin resistance (IR) is linked to higher red blood cell (RBC) and white blood cell (WBC) counts. This study suggests these blood cell count changes may indicate underlying IR syndrome.
Area of Science:
- Endocrinology
- Hematology
- Metabolic Syndrome
Background:
- Insulin resistance (IR) is linked to erythroid progenitor stimulation and inflammation.
- Previous findings suggest a potential association between IR and altered blood cell counts.
Purpose of the Study:
- To investigate the independent association between IR and hematological parameters.
- To analyze these associations in a Brazilian population sample.
Main Methods:
- Analysis of laboratorial exams from 925 subjects.
- Inclusion of data on hematological parameters, insulin resistance (Homeostasis Model Assessment [HOMA]), and lipid levels.
- Consideration of demographic information including age and gender.
Main Results:
- HOMA showed positive correlations with RBC, plasma hemoglobin, hematocrit, and WBC counts.
- Subjects in the highest quartile of IR exhibited elevated levels of glucose, insulin, triglycerides, hematocrit, hemoglobin, RBC, and WBC compared to the lowest quartile.
Conclusions:
- Insulin resistance appears to be associated with significant alterations in multiple hematological parameters.
- These hematological changes could serve as indirect indicators of the IR syndrome.
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