Related Experiment Video
Updated: Aug 9, 2026

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
Published on: September 28, 2016
Cl⁻ channels: what role do they play in mammalian heart?
1Institute of Basic Medical Sciences, Department of Physiology, Medical College, Dalian University, Dalian 116622, China. zhouss@dlu.edu.cn
Abstract:
Cl(-) channel has been identified in heart over more than a decade. It is now known that Cl(-) channel is a super-family. The potentially important roles of cardiac Cl(-) channels have been emerging. Cardiac Cl(-) channels may play multifunctional roles in both physiological and pathophysiological conditions. Since the existence and distribution of cardiac Cl(-) channels vary with species and cardiac tissues, and blockade of Cl (-) channel with putative Cl(-) channel blockers or Cl(-) substitution has profound influence on cardiac electrical properties, it appears that the main role of cardiac Cl(-) channels may be to modulate cation channels or provide an ionic environment suitable for the activities of cation channels. So, to investigate the relationship between Cl(-) channels and cation channels may be of physiological and pathophysiological significance.
Related Concept Videos
G-Protein Gated Ion Channels
Sensory organs,...
Gap Junctions
Gap Junctions
Voltage-gated Ion Channels
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Ion Channels
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific...
Chambers of the Heart
Deoxygenated blood from the body is received in the right...

