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Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report
Olivier Rozenbaum1, Flore Rozenberg, Frederic Charlotte
1Department of Ophthalmology, University of Paris VI Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
Background:
To report a case of severe acute retinal necrosis syndrome (ARN) associated with initial features of orbital cellulitis.
Methods:
A 49-year-old immunocompetent woman presented with unilateral painful orbital inflammation associated with deep visual loss due to ARN. Polymerase chain reaction (PCR) for detection of viral DNA was applied to ocular fluids. Immunohistochemistry for detection of viral antigens and histopathologic studies were performed on orbital biopsy specimens.
Results:
HSV-2 DNA was detected by PCR in ocular fluids. Orbital biopsy disclosed non-specific inflammation without viral replication. Orbital inflammation resolved rapidly after the initiation of antiviral drugs, whereas intraocular inflammation worsened. Final ophthalmic examination disclosed no light perception due to optic atrophy.
Conclusion:
ARN and cellulitis may be associated. Consequently, ARN should be investigated in all patients with orbital inflammation, in order to initiate immediately an appropriate antiviral strategy.