Related Experiment Video
Updated: Aug 17, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
In vitro activity of temafloxacin against pathogens causing sexually transmitted diseases
1Section of Infectious Diseases, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Abstract:
The fluoroquinolones represent a new therapeutic alternative for the treatment of many sexually transmitted diseases, especially those caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma hominis, and Urea-plasma urealyticum. In vitro studies have demonstrated the 90% minimal inhibitory concentrations (MIC90s) of temafloxacin for these pathogens to be less than 0.03 micrograms/mL for N. gonorrhoeae; 0.25 micrograms/mL for C. trachomatis; 0.125-2 micrograms/mL for M. hominis; and 4 micrograms/mL for U. urealyticum. These concentrations are equal to or less than those achievable in plasma following a 400-mg temafloxacin oral dose given twice daily. Based on temafloxacin's antimicrobial activity and pharmacokinetic profile, it appears to be an excellent agent for the treatment of patients with gonococcal or nongonococcal urethritis and/or cervicitis.
Related Concept Videos
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Sexually Transmitted Infections
Antimicrobial Effectiveness
Trichomoniasis
Inhibitors of Bacterial DNA Synthesis

