Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The functional links between prion protein and copper.

Lorena Varela-Nallar1, Enrique M Toledo, Marcelo A Chacón

  • 1Centro de Regulación Celular y Patología "Joaquin V. Luco" (CRCP), MIFAB, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Biological Research
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fructose Intake Is Associated with Brain Metabolic Reprogramming and Exacerbation of Alzheimer-like Alterations in APP/PS1 Mice.

International journal of molecular sciences·2026
Same author

Distinct radial glia subtypes regulate midbrain dopaminergic neuron development.

Nature neuroscience·2026
Same author

Human-derived cardiac-neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron.

The Journal of physiology·2026
Same author

Metabolic Reprogramming by Andrographolide: Enhanced Pentose Phosphate Pathway and Antioxidant Capacity in Cortical Astrocytes.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Viral-mediated fluorescent labelling of activated hippocampal memory engrams to study epigenetic dynamics associated with gene expression.

Methods (San Diego, Calif.)·2026
Same author

Adipokines at the Metabolic-Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer's Disease.

Pharmaceuticals (Basel, Switzerland)·2025

Cellular prion protein (PrPC) interacts with copper, potentially playing a role in neuroprotection and disease. This study explores the physiological link between PrPC and copper metabolism in the brain.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Molecular Biology

Background:

  • Prion diseases involve the misfolding of cellular prion protein (PrPC) into a pathogenic form.
  • The exact physiological role of PrPC is not fully understood.
  • PrPC exhibits copper-binding properties in its N-terminal region, suggesting a link to copper metabolism.

Purpose of the Study:

  • To investigate the physiological connection between PrPC and copper metabolism.
  • To explore the neuroprotective role of PrPC in relation to copper.
  • To discuss the relevance of PrPC interactions with heparan sulfate proteoglycans.

Main Methods:

  • In vitro studies of PrPC's copper-binding and reduction capabilities.
  • In vivo experiments examining PrPC function.

Related Experiment Videos

  • Analysis of PrPC gene regulation, including metal response elements.

    • Main Results:

    • The N-terminal octapeptide repeat region of PrPC binds and reduces copper ions.
    • This copper-binding ability is linked to neuroprotection against copper toxicity in vivo.
    • Evidence suggests PrPC gene regulation by heavy metals via promoter elements.

    Conclusions:

    • PrPC plays a significant role in copper metabolism and cellular protection.
    • Understanding PrPC-copper interactions is crucial for neurodegenerative disease research.
    • PrPC's interaction with heparan sulfate proteoglycans is physiologically relevant.