Effects of 2'-demethoxy-2'-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells
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1Department of Pharmaceutical Sciences, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo 105-8512, Japan.
Abstract:
Griseofulvin may combine with tubulin as a component of microtubules and, at high doses, inhibits microtubule formation in mammalian cells. In this study, the author examined the effects of three various 2'-substitutive derivatives of griseofulvin on microtubule distribution in Chinese hamster V79 cells. The results showed that 2'-demethoxy-2'propoxygriseofulvin was the strongest inhibitor of a normal cytoplasmic microtubule network, unlike findings in previous in-vitro studies.
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