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Related Experiment Video

Updated: Jan 4, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Published on: April 5, 2016

Collateral sprouting as a target for improved function after spinal cord injury.

¹Kentucky Spinal Cord Injury Research Center, Department of Neurological Surgery, University of Louisville, Louisville, Kentucky 40292, USA. theo.hagg@louisville.edu

Journal of Neurotrauma

|April 25, 2006

Summary

This summary is machine-generated.

Collateral sprouting, the growth of new axons, may aid motor recovery after spinal cord injury but can cause sensory issues. Research is exploring ways to enhance beneficial sprouting and reduce harmful sprouting.

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Published on: July 27, 2014

Area of Science:

Neuroscience
Regenerative Medicine
Spinal Cord Injury Research

Background:

Functional recovery after spinal cord injury (SCI) is a major challenge.
Enhancing innervation through collateral sprouting is a potential therapeutic strategy.
Collateral sprouting involves new axon growth along existing axons.

Purpose of the Study:

To review spontaneous collateral sprouting in SCI animal models.
To discuss experimental strategies for modulating sprouting for improved function.
To explore signaling mechanisms regulating axonal branching.

Main Methods:

Literature review of animal studies on spinal cord injury.
Analysis of experimental treatments targeting collateral sprouting.
Examination of cell-surface and intracellular signaling pathways.

Main Results:

Spontaneous collateral sprouting occurs in both motor and sensory systems post-SCI in animal models.
Experimental strategies aim to promote motor system sprouting and inhibit sensory sprouting.
Sensory sprouting is linked to autonomic dysreflexia and pain.

Conclusions:

Knowledge of collateral sprouting in adult mammals post-SCI is limited.
Collateral sprouting may contribute to spontaneous motor recovery and sensory dysfunction.
Rodent studies show promise for modulating sprouting, but human relevance is undetermined.