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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Serum Fas and Bcl-2 in patients with epilepsy

M A El-Hodhod1, H Y Tomoum, M M Abd Al-Aziz

  • 1Department of Pediatrics, Ain Shams University, Cairo, Egypt. hoda_tomoum@yahoo.com

Acta Neurologica Scandinavica
|April 25, 2006
PubMed

Insights

Markers of apoptosis, soluble Fas (s.Fas) and Bcl-2, are elevated in children with idiopathic epilepsy. Higher levels correlate with increased seizure severity and frequency, indicating their role in epilepsy progression.

Area of Science:

  • Biochemistry
  • Neurology
  • Pediatrics

Background:

  • Idiopathic epilepsy is a common neurological disorder in children and adolescents.
  • Apoptosis plays a role in various neurological conditions.
  • Biochemical markers of apoptosis, such as soluble Fas (s.Fas) and Bcl-2, may be implicated in epilepsy pathogenesis.

Purpose of the Study:

  • To investigate serum levels of the apoptosis markers, soluble Fas (s.Fas) and Bcl-2, in pediatric patients with idiopathic epilepsy.
  • To explore the relationship between these markers and clinical characteristics of epilepsy, including seizure type, severity, and frequency.

Main Methods:

  • A case-control study involving 30 children and adolescents with idiopathic epilepsy and 15 healthy controls.
  • Serum s.Fas and Bcl-2 levels were measured using enzyme-linked immunosorbent assay (ELISA).
  • Correlation analysis was performed to assess relationships between marker levels and epilepsy parameters.

Main Results:

  • Serum levels of both s.Fas and Bcl-2 were significantly higher in patients with idiopathic epilepsy compared to controls.
  • Elevated levels of s.Fas and Bcl-2 were observed in patients with uncontrolled epilepsy.
  • s.Fas levels correlated positively with seizure severity and negatively with time since last seizure.
  • Bcl-2 levels correlated positively with epilepsy duration, seizure severity, and frequency.

Conclusions:

  • Proapoptotic (Fas) and anti-apoptotic (Bcl-2) markers are elevated in pediatric idiopathic epilepsy.
  • These elevated apoptosis markers are associated with increased seizure severity and frequency.
  • The findings suggest a role for apoptosis dysregulation in the pathophysiology of idiopathic epilepsy.
Abstract

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