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Vascular endothelial growth factor gene polymorphisms increase the risk to develop psoriasis.

S Barile1, E Medda, L Nisticò

  • 1Department of Dermatology, S. Gallicano Institute, Rome, Italy.

Experimental Dermatology
|April 25, 2006
PubMed
Summary
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Certain vascular endothelial growth factor (VEGF) gene polymorphisms significantly increase the risk of developing late-onset plaque-type psoriasis. These specific VEGF genotypes are associated with a higher risk of psoriasis after age 40.

Area of Science:

  • Genetics and Molecular Biology
  • Dermatology
  • Immunology

Background:

  • Plaque-type psoriasis is a chronic inflammatory skin condition with a complex genetic basis.
  • Vascular Endothelial Growth Factor (VEGF) plays a role in angiogenesis and immune cell function, potentially influencing psoriasis pathogenesis.
  • Genetic variations in the VEGF gene may be associated with susceptibility to psoriasis.

Purpose of the Study:

  • To investigate the association between eight specific polymorphisms in the vascular endothelial growth factor (VEGF) gene and plaque-type psoriasis.
  • To analyze these associations stratified by age at onset, gender, and family history of dermatosis.
  • To determine if VEGF plasma concentration correlates with disease severity.

Main Methods:

  • Genotyping of eight VEGF gene polymorphisms (-1540C > A, -1512Ins18, -1451C > T, -460T > C, -160C > T, -152G > A, -116G > A, +405G > C) in 117 chronic plaque-type psoriasis patients and 215 healthy controls.

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  • Statistical analysis including odds ratios (ORs) to assess the risk associated with different genotypes.
  • Stratification analysis based on age at onset (early vs. late), gender, and family history.
  • Measurement of VEGF plasma concentration.

    • Main Results:

    • Homozygous genotypes (-1540AA, -1512InsIns, -1451TT, -460CC, -152AA) significantly increased the risk of developing psoriasis (ORs ranging from 1.73 to 1.87).
    • These specific homozygous genotypes showed a significant two-fold increased risk for late-onset psoriasis (after age 40).
    • No significant associations were found for -116AA or +405GG genotypes, nor for early-onset psoriasis, gender, or family history stratification. VEGF plasma levels did not differ between patients and controls or correlate with disease severity.

    Conclusions:

    • Specific homozygous polymorphisms in the VEGF gene (-1540AA, -1512InsIns, -1451TT, -460CC, -152AA) are significant risk factors for developing plaque-type psoriasis, particularly late-onset forms.
    • These findings highlight the role of VEGF genetic variations in psoriasis susceptibility, especially in individuals developing the disease after 40 years of age.
    • VEGF genotype does not appear to influence disease severity or be associated with gender or family history in this cohort.