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Infrequent existence of simian virus 40 large T antigen DNA in malignant mesothelioma in Japan

Keisuke Aoe1, Akio Hiraki, Tomoyuki Murakami

  • 1Department of Respiratory Medicine, NHO Sanyo National Hospital, 685 Higashi-kiwa, Ube, Yamaguchi 755-0241, Japan. keisukeaoe@mtf.biglobe.ne.jp

Cancer Science
|April 25, 2006
PubMed

Insights

Simian virus 40 (SV40) DNA was detected in 2 of 35 Japanese malignant mesothelioma cases, but the virus protein was not found. SV40 infection likely does not play a major role in malignant mesothelioma development in Japan.

Area of Science:

  • Oncology
  • Virology
  • Pathology

Background:

  • Malignant mesothelioma is a primary pleural neoplasm.
  • Simian virus 40 (SV40) association with malignant mesothelioma suggests a role in tumor origin.
  • Geographic variations exist in the frequency of SV40 association with mesothelioma.

Purpose of the Study:

  • To investigate the frequency of SV40 infection in Japanese malignant mesothelioma cases.
  • To determine the role of SV40 in the etiology of malignant mesothelioma in Japan.

Main Methods:

  • Analysis of 35 malignant pleural mesothelioma tissue samples from Japan.
  • Real-time polymerase chain reaction (PCR) to detect SV40 large T antigen DNA.
  • Immunohistological methods to detect SV40 large T antigen protein expression.

Main Results:

  • SV40 large T antigen DNA sequences were detected in 2 out of 35 (5.7%) mesothelioma specimens.
  • None of the 35 malignant mesothelioma specimens showed immunoreactivity for SV40 large T antigen.
  • The presence of SV40 DNA without protein expression suggests limited viral activity.

Conclusions:

  • SV40 infection does not appear to play a significant role in the development of malignant mesothelioma in the Japanese population.
  • Further research may be needed to understand the specific mechanisms of mesothelioma in Japan.

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