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Oral malignant melanoma associated with pseudoepitheliomatous hyperplasia. Report of a case

Marco Meleti1, Wolter J Mooi, Isaäc van der Waal

  • 1Unit of Oral Pathology and Medicine, Section of Odontostomatology, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Parma, Italy.

Journal of Cutaneous Pathology
|April 25, 2006
PubMed
Abstract

Insights

Pseudoepitheliomatous hyperplasia (PEH) is a rare oral condition. This study describes a unique case of PEH in malignant melanoma of the palate, highlighting its rarity and distinct origin from cutaneous melanoma.

Area of Science:

  • Oral pathology
  • Dermatopathology
  • Oncology

Background:

  • Pseudoepitheliomatous hyperplasia (PEH) is a reactive epithelial proliferation mimicking squamous cell carcinoma.
  • PEH is associated with various skin and mucous membrane conditions, including nevi, but not previously with oral malignant melanoma.

Purpose of the Study:

  • To report a rare case of pseudoepitheliomatous hyperplasia (PEH) occurring in conjunction with malignant melanoma of the palate.
  • To investigate the potential origin of PEH in oral malignant melanoma.

Main Methods:

  • Case report of a 46-year-old female patient with oral malignant melanoma and PEH.
  • Comprehensive English literature search for similar reported cases.

Main Results:

  • A unique case of pseudoepitheliomatous hyperplasia (PEH) was identified in a patient with malignant melanoma of the palate.
  • No prior reports of PEH associated with oral malignant melanoma were found in the literature.

Conclusions:

  • Pseudoepitheliomatous hyperplasia (PEH) associated with oral malignant melanoma is exceptionally rare.
  • PEH in oral malignant melanoma likely arises from the surface epithelium, differing from cutaneous melanoma where follicular or eccrine units are implicated.

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