Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surgery for locally advanced disease.

Philippe E Spiess1, Dan Leibovici, Louis L Pisters

  • 1Department of Urology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373, Houston, TX 77030, USA.

Current Urology Reports
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do Urologists Adhere to Antibiotic Prophylaxis Guidelines prior to Cystoscopy?

Urologia internationalis·2026
Same author

Low Testosterone Levels and Grade Group Progression Among Localized Prostate Cancer Patients on Active Surveillance: A Retrospective Cohort Study.

The Journal of urology·2026
Same author

Sex differences in the association of emotional approach coping with stress and quality of life among patients with renal cell carcinoma.

Palliative & supportive care·2026
Same author

Influence of Prostate Volume on Targeted Biopsy Outcomes and PI-RADS Predictive Value for Significant Prostate Cancer.

Journal of clinical medicine·2025
Same author

Randomized Phase 2 Trial of Presurgical Androgen Deprivation Therapy With or Without Axitinib in Prostate Cancer Presenting With Lymph Node Metastasis.

European urology oncology·2025
Same author

Bilateral Germ Cell Tumor of the Testis: Biological and Clinical Implications for a Stem Versus Genetic Origin of Cancers.

Cells·2025
Same journal

Single Port Robotic Surgery in Benign Urologic Disease - A Review of Contemporary Applications and Outcomes.

Current urology reports·2026
Same journal

Effective Mentorship in Urology Fellowship Training: Qualities, Models, and Equity.

Current urology reports·2026
Same journal

Management of Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis.

Current urology reports·2026
Same journal

Lower Urinary Tract Symptoms as an Indicator of Occult Neurologic Disease: A System-first Framework for Urologic Practice.

Current urology reports·2026
Same journal

Association Between Ambient Temperature and Urolithiasis: A Systematic Review and Meta-analysis.

Current urology reports·2026
Same journal

Is Open Partial Nephrectomy Still an Option in the Robotic Era?

Current urology reports·2026
See all related articles

Locally advanced prostate cancer requires advanced treatment. Multimodality therapy, including surgery and chemohormonal treatments, shows promise for improving outcomes and reducing mortality in these patients.

Area of Science:

  • Urology
  • Oncology
  • Surgical Oncology

Background:

  • Locally advanced prostate cancer constitutes about 25% of new prostate cancer diagnoses.
  • Monotherapy with surgery or radiotherapy yields a high disease-specific mortality rate of 75%.

Purpose of the Study:

  • To review the surgical management of locally advanced prostate cancer.
  • To summarize anatomic features and technical concepts for optimizing surgical outcomes.
  • To review outcomes of surgery combined with neoadjuvant or adjuvant chemohormonal therapy.

Main Methods:

  • Review of anatomic features and technical concepts in surgical management.
  • Analysis of published outcomes data for surgery.
  • Evaluation of neoadjuvant or adjuvant chemohormonal therapy in conjunction with surgery.

Related Experiment Videos

Main Results:

  • Multimodality treatment approaches may offer improved results compared to monotherapy.
  • Specific surgical techniques and understanding of anatomic features can optimize oncologic control and minimize morbidity.
  • Outcomes data for combined modality treatments are being reviewed.

Conclusions:

  • A multimodality approach is recommended for locally advanced prostate cancer.
  • Surgical management requires careful consideration of anatomic factors and technical execution.
  • Further research into combined therapies is warranted to improve patient survival and quality of life.