Related Experiment Video
Updated: Aug 9, 2026

Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment
Published on: September 25, 2017
Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus
1Department of Pathology, Anatomy, and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Abstract:
A significant functional role for epidermal growth factor receptor (EGFR) in the suprachiasmatic nucleus (SCN) is suggested by the confluence of several recent findings: (1) EGFR is highly expressed in the SCN, (2) the EGFR ligand TGFalpha is expressed and apparently locally released in the SCN, and (3) EGFR activation local to the 3rd ventricle suppresses circadian locomotor behavior and drinking/feeding activities. However, it has not yet been shown that binding of EGFR in the SCN can activate the key signaling pathways associated with its function. Here, we report that EGF treatment induced Erk1/2 phosphorylation in the rat SCN cells. The observation indicates functional EGFR in the SCN and motivates further investigation of the functional role of these receptors.
Related Concept Videos
MAPK Signaling Cascades
Mitogens and the Cell Cycle
Amplifying Signals via Enzymatic Cascade
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
PI3K/mTOR/AKT Signaling Pathway
Cell Signaling in Plants

