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Published on: January 22, 2016
Worsening of obsessive-compulsive symptoms under methadone tapering
Yasser Khazaal1, Sonia Krenz, Messaoud Benmebarek
1Département Universitaire de Psychiatrie Adulte, Prilly - Lausanne, Switzerland. yasser.khazaal@chuv.ch <yasser.khazaal@chuv.ch>
Abstract:
There is data supporting the hypothesis that the endogenous opioid system may play a role in the pathophysiology of Obsessive Compulsive Disorder (OCD). The authors report a case of worsening of OCD during methadone tapering, which seems to confirm the role of the opioid system in the pathophysiology of OCD. The possible involvement of the cortico-limbic-basal-ganglia-thalamic circuit in the observed phenomenon is discussed.
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