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Updated: Jan 31, 2026

One-anastomosis Gastric Bypass OAGB in Rats
Published on: November 10, 2018
Pten, tumorigenesis, and stem cell self-renewal
Derrick J Rossi1, Irving L Weissman
1Department of Pathology, Stanford University School of Medicine, Beckman Center B259, 279 Campus Drive, Stanford, CA 94305, USA. drossi@stanford.edu
Abstract:
Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As Yilmaz et al. (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms.
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