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Related Experiment Videos

Murine taste-immune associative learning.

Maj-Britt Niemi1, Gustavo Pacheco-López, Wei Kou

  • 1Institute for Behavioral Sciences, ETH Zurich, Zurich 8092, Switzerland.

Brain, Behavior, and Immunity
|April 25, 2006
PubMed
Summary

Mice can learn to associate a taste with the immunosuppressant drug cyclosporine A (CsA), leading to reduced immune responses without changing their behavior towards the taste.

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Area of Science:

  • Neuroimmunology
  • Behavioral immunology
  • Psychoneuroimmunology

Background:

  • Taste-immune associative learning links gustatory stimuli with immune responses.
  • Cyclosporine A (CsA) and saccharin were previously used to model this in rats and humans.
  • Investigating inter-species generalization of this neuro-immune interaction is crucial.

Purpose of the Study:

  • To test the feasibility of taste-immune associative learning in mice using CsA.
  • To determine if mice exhibit conditioned immunosuppression without behavioral avoidance.
  • To compare this with taste aversion learning using lithium chloride.

Main Methods:

  • Male BALB/c mice were conditioned with saccharin (CS) and CsA (US) over three trials.
  • Control groups assessed associative learning, drug effects, and placebo.

Related Experiment Videos

  • Immune response was measured by T-lymphocyte proliferation and IL-2 production in the spleen.

    • Main Results:

    • CsA-conditioned mice showed significant splenic immunosuppression after recall.
    • No avoidance behavior towards saccharin was observed in CsA-conditioned mice.
    • Mice conditioned with saccharin and lithium chloride exhibited strong taste avoidance and immunosuppression.

    Conclusions:

    • Mice can form taste-CsA associations, resulting in conditioned immunosuppression.
    • This conditioned immunosuppression occurs without altering appetitive behavior.
    • The findings demonstrate inter-species generalization of taste-immune learning in mice.