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Triplex forming ability of oligonucleotides containing 2'-O-methyl-2-thiouridine or 2-thiothymidine

Itaru Okamoto1, Kohji Seio, Mitsuo Sekine

  • 1Department of Life Science, Tokyo Institute of Technology, Japan.

Bioorganic & Medicinal Chemistry Letters
|April 25, 2006
PubMed
Summary

Modified oligonucleotides with 2-thiocarbonyl groups significantly stabilize parallel triplexes. These triplex forming oligonucleotides (TFOs) demonstrate high selectivity for matched DNA bases.

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