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Studies on experimental Jembrana disease in Bali cattle. III. Pathology
D M Dharma1, A Budiantono, R S Campbell
1Bali Cattle Disease Investigation Unit, Denpasar, Indonesia.
Journal of Comparative Pathology
|November 1, 1991
Summary
Experimental Jembrana disease infection in Bali cattle causes widespread pathology, primarily affecting lymphoid organs, kidneys, and lungs. Intracytoplasmic inclusions in various cells are key diagnostic indicators.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Bovine Medicine
Background:
- Jembrana disease is a significant pathological condition affecting Bali cattle (Bos sondaicus).
- Understanding the disease's progression and cellular response is crucial for diagnosis and management.
Purpose of the Study:
- To detail the pathological and cytological changes following experimental Jembrana disease infection in Bali cattle.
- To identify potential diagnostic markers for Jembrana disease.
Main Methods:
- Experimental infection of Bali cattle using blood from a Jembrana disease case.
- Histopathological and cytological examination of various tissues at different time points post-infection.
Main Results:
- Generalized pathological response observed, with significant lymphoreticular reactions, lymphoid organ proliferation, and kidney/lung involvement.
- Distinct phases of disease progression noted, including acute lymphoreticular changes and later follicular reactions.
- Pleomorphic basophilic intracytoplasmic inclusions identified in various cell types, appearing from week two and persisting for over two months.
Conclusions:
- The study elucidates the distinct pathological progression of Jembrana disease in Bali cattle.
- Intracytoplasmic inclusions are identified as valuable diagnostic indicators for Jembrana disease.
- A predominantly T-lymphocytic reaction during the acute phase may suggest transient immunosuppression.