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Related Experiment Videos

Fixation of titanium and hydroxyapatite-coated implants in arthritic osteopenic bone.

K Søballe1, E S Hansen, H Brockstedt-Rasmussen

  • 1Biomechanics Laboratory, Orthopaedic Hospital, University of Aarhus, Denmark.

The Journal of Arthroplasty
|December 1, 1991
PubMed
Summary

Hydroxyapatite (HA) coating improves bony ingrowth and fixation of porous titanium implants in osteopenic bone. HA-coated implants showed consistent performance, unlike uncoated titanium implants, in this dog model study.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Bone Biology

Background:

  • Porous-coated prostheses retrieval studies indicate high rates of deficient bony ingrowth.
  • Lack of initial mechanical stability and osteopenia are potential causes for poor bony integration.

Purpose of the Study:

  • To investigate bony ingrowth into titanium alloy (Ti) porous-coated implants with and without hydroxyapatite (HA) coating in experimentally induced osteopenic bone.
  • To evaluate the effect of osteopenia on implant fixation and shear strength.

Main Methods:

  • Unilateral osteopenia was induced in 12 dogs' knees using Carragheenin injections.
  • Ti porous-coated cylinders and HA-coated titanium plugs were implanted in femoral condyles.
  • Bony ingrowth and bone-implant shear strength were assessed after 4 weeks.

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Main Results:

  • Bony ingrowth was significantly reduced for Ti implants in osteopenic bone versus control bone.
  • HA-coated implants demonstrated equal bone coverage in both osteopenic and control bone.
  • Bone-implant shear strength of Ti implants decreased in osteopenic bone, while HA-coated implants maintained fixation.

Conclusions:

  • Experimentally induced osteopenia weakens the bony fixation of Ti porous-coated implants.
  • HA coating mitigates the negative impact of osteopenia on implant fixation.
  • HA-coated implants offer comparable fixation to Ti implants in osteopenic bone, outperforming them in control bone.