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Mechanical reliability of the Jarvik 2000 Heart.

Michael P Siegenthaler1, O H Frazier, Friedhelm Beyersdorf

  • 1Center for Cardiovascular Disease, University of Freiburg, Freiburg, Germany. siegenth@ch11.ukl.uni-freiburg.de

The Annals of Thoracic Surgery
|April 25, 2006
PubMed
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The Jarvik 2000 Heart demonstrated excellent mechanical reliability with no implantable component failures in over 110 years of combined use. This axial flow pump shows promise for long-term mechanical circulatory support in heart failure patients.

Area of Science:

  • Cardiovascular Engineering
  • Biomedical Device Technology
  • Heart Failure Management

Background:

  • Permanent mechanical circulatory support devices are limited by device failure.
  • The Jarvik 2000 Heart is an axial flow pump designed for enhanced durability.
  • Ceramic bearings are a key feature for long-term performance.

Purpose of the Study:

  • To evaluate the mechanical reliability and durability of the Jarvik 2000 Heart.
  • To assess the device's performance in both clinical use and bench testing.
  • To establish failure modes and long-term support capabilities.

Main Methods:

  • Implanted the Jarvik 2000 Heart in 102 patients (April 2000 - December 2004).
  • Utilized abdominal drivelines for bridge-to-transplantation (83 pumps) and postauricular power for lifetime therapy (19 pumps).

Related Experiment Videos

  • Conducted bench testing on 18 explanted pumps for continuous durability assessment.

    • Main Results:

    • Achieved zero implantable component failures in patients or during bench testing.
    • Accumulated 110 years of total pump run-time (59 years in vivo, 51 years in vitro).
    • External cable issues caused three system failures, but no adverse patient consequences; 95% freedom from system failure at 4 years.

    Conclusions:

    • The Jarvik 2000 Heart exhibits exceptional implantable component reliability.
    • Real-time patient data is crucial for establishing comprehensive durability and failure mode analysis.
    • The device's dependability and interchangeable external components offer significant potential for long-term circulatory support in severe heart failure.