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Related Experiment Videos

Neocortical volume decrease in relapsing-remitting multiple sclerosis with mild cognitive impairment.

Emilio Portaccio1, Maria Pia Amato, Maria Letizia Bartolozzi

  • 1Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. portilio@tin.it

Journal of the Neurological Sciences
|April 25, 2006
PubMed
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Cognitively impaired individuals with early relapsing-remitting multiple sclerosis (RRMS) show reduced neocortical brain volumes. This cortical atrophy correlates with cognitive deficits, suggesting grey matter changes contribute to early MS cognitive impairment.

Area of Science:

  • Neuroscience
  • Radiology
  • Neurology

Background:

  • Relapsing-remitting multiple sclerosis (RRMS) is a central nervous system autoimmune disease.
  • Cognitive impairment is a common and early manifestation of MS.
  • Neocortical changes are increasingly recognized as a significant factor in MS-related cognitive decline.

Purpose of the Study:

  • To investigate neocortical volume changes in early RRMS.
  • To determine the association between neocortical volume and cognitive function in RRMS patients.
  • To explore the role of grey matter pathology in early cognitive impairment in MS.

Main Methods:

  • Conventional magnetic resonance imaging (MRI) was used to acquire brain scans from 41 RRMS patients and 16 healthy controls (NC).
  • An automated analysis tool quantified normalized cortical volumes (NCV).

Related Experiment Videos

  • Neuropsychological testing, including Rao's Brief Repeatable Battery, assessed cognitive performance.

    • Main Results:

    • RRMS patients exhibited lower NCV compared to NC (p=0.01).
    • Cognitively impaired MS patients (MS-ci) had significantly lower NCV than cognitively preserved MS patients (MS-cp) and NC (p=0.02).
    • In MS-ci patients, NCV positively correlated with verbal memory, verbal fluency, and attention/concentration, and negatively with the number of impaired cognitive tests.

    Conclusions:

    • Neocortical volume reduction is present in early RRMS and is associated with cognitive impairment.
    • Cortical atrophy in MS-ci patients is significantly correlated with poorer neuropsychological performance.
    • Grey matter pathology likely contributes to cognitive impairment in the early stages of multiple sclerosis.