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BDNF: a missing link between sympathetic dysfunction and inflammatory disease?

Lora J Kasselman1, Alexandra Sideris, Chantal Bruno

  • 1Neuropsychology Doctoral Subprogram, Graduate Center of the City University of New York, USA.

Journal of Neuroimmunology
|April 25, 2006
PubMed
Summary
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Brain-derived neurotrophic factor (BDNF) combined with compromised sympathetic neurons induces perivascular inflammation and vasoconstriction. This suggests BDNF may transform sympathetic dysfunction into inflammatory vascular disease.

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Immunology

Background:

  • Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) support sympathetic neuron survival.
  • Sympathetic nervous system dysfunction is implicated in various vascular diseases.

Purpose of the Study:

  • To investigate the effect of combined BDNF and sympathetic compromise on vascular health.
  • To explore the potential role of BDNF in the development of inflammatory vascular disease.

Main Methods:

  • Co-treatment of hippocampus with BDNF and NGF antagonist (TrkA-Fc) in vivo.
  • Surgical removal of superior cervical ganglia to induce sympathetic compromise.
  • Concurrent infusion of BDNF and norepinephrine (NE) into the hippocampus.

Related Experiment Videos

Main Results:

  • Co-treatment with BDNF and TrkA-Fc induced perivascular inflammation and vasoconstriction.
  • Sympathetic nerve terminals were necessary for the observed inflammation.
  • Co-infusion of BDNF and NE also resulted in perivascular inflammation.

Conclusions:

  • BDNF, in conjunction with sympathetic nervous system dysfunction, can trigger perivascular inflammation.
  • This mechanism may contribute to the transition from sympathetic overactivity to inflammatory vascular conditions.
  • BDNF's role in vascular disease warrants further investigation.