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Updated: Aug 9, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
Germline mutations and gene polymorphism associated with human pancreatitis
F Ulrich Weiss1, Peter Simon, Julia Mayerle
1Department of Gastroenterology, Endocrinology, and Nutrition, Ernst-Moritz-Arndt Universität Greifswald, Friedrich-Loeffler-Strasse 23A, 17485 Greifswald, Germany.
Abstract:
A wide range of mutations and polymorphisms in genes that relate to pancreatic function seem to be involved in the development of pancreatitis. Some of these genetic alterations lead to disease phenotypes with unequivocal mendelian inheritance patterns, whereas others seem to act as modifier genes in conjunction with environ-mental or, as yet unidentified, genetic cofactors. This article reviews germline changes in the genes for trypsin, pancreatic secretory trypsin inhibitor, the cystic fibrosis conductance regulator, lipid metabolism proteins, inflammatory mediators for cytokines, and cathepsin B.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
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