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Related Experiment Videos

Development of a dermal cancer slope factor for benzo[a]pyrene.

A Knafla1, K A Phillipps, R W Brecher

  • 1Equilibrium Environmental Inc., Suite 609, 815 1st Street SW Calgary, Alta., Canada T2P 1N3.

Regulatory Toxicology and Pharmacology : RTP
|April 25, 2006
PubMed
Summary

This study derives a cancer slope factor for dermal exposure to polycyclic aromatic hydrocarbons (PAHs), using benzo[a]pyrene (B[a]P) as a standard. The findings provide a new estimate for human health risk assessment of dermal PAH exposure.

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Area of Science:

  • Environmental Science
  • Toxicology
  • Risk Assessment

Background:

  • Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants.
  • Benzo[a]pyrene (B[a]P) is a standard for comparing carcinogenic PAHs.
  • Regulatory agencies lack a cancer potency estimate for dermal PAH exposure.

Purpose of the Study:

  • Evaluate PAH carcinogenicity assessment approaches.
  • Review dermal carcinogenicity studies of B[a]P.
  • Derive a cancer slope factor for dermal PAH exposure using B[a]P.

Main Methods:

  • Reviewed seven relevant mammalian dermal carcinogenicity studies of B[a]P.
  • Applied benchmark dose approach and linearized multistage model.
  • Used upper 95th CI at 5% effect level for low-dose extrapolation.

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Main Results:

  • Calculated an average dermal slope factor of 0.55 (µg/animal/day)⁻¹ for mice.
  • Converted to a dose-equivalent slope factor of 25 (mg/kg/day)⁻¹ for human health risk assessment.
  • Identified dermal potency equivalency factors for other carcinogenic PAHs.

Conclusions:

  • The derived slope factor of 25 (mg/kg/day)⁻¹ is proposed for human health risk assessment.
  • Further investigation is needed on scaling from mice to humans.
  • Dermal potency equivalency factors can aid in calculating total B[a]P equivalent dermal cancer risk.