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Related Experiment Videos

Retroperitoneal fibrosis after chemotherapy.

Ambrogio Fassina1, Rafael Boscolo Berto, Rafi El Mazloum

  • 1Department of Pathology, Medical School, University of Padova, Padova, Italy. ambrogio.fassina@unipd.it

European Urology
|April 25, 2006
PubMed
Summary
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Chemotherapy can cause retroperitoneal fibrosis (RPF), a rare condition, in patients with non-Hodgkin lymphoma. Diagnosis requires tissue examination, highlighting chemotherapy as a potential RPF cause.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Non-Hodgkin lymphoma (NHL) is a hematologic malignancy.
  • Retroperitoneal fibrosis (RPF) is a rare condition characterized by excessive fibrous tissue in the retroperitoneum.

Observation:

  • A patient with NHL developed RPF after standard chemotherapy.
  • No radiotherapy or other known causes for RPF were identified.

Findings:

  • Microscopic examination of fine-needle aspiration and true-cut biopsy confirmed RPF.
  • The findings suggest a direct link between chemotherapy and RPF development.

Implications:

  • Chemotherapy alone, without radiotherapy, can induce RPF.
  • This case expands the understanding of chemotherapy-induced adverse events.

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  • Clinicians should consider RPF in patients with NHL undergoing chemotherapy presenting with relevant symptoms.