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Related Experiment Videos

Prolactin synthesis by lymphocytes from patients with systemic sclerosis.

Joanna Czuwara-Ladykowska1, Justyna Sicinska, Malgorzata Olszewska

  • 1Department of Dermatology CSK MSWiA, ul. Wołoska 137, 02-507 Warsaw, Poland. czuwaraj@yahoo.com

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|April 25, 2006
PubMed
Summary

Systemic sclerosis patients show elevated prolactin levels due to increased lymphocyte production. Lowering prolactin may benefit patients with this autoimmune disease.

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Area of Science:

  • Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease marked by fibrosis.
  • Elevated serum prolactin is observed in connective tissue diseases.

Purpose of the Study:

  • Investigate the source of excess prolactin in SSc.
  • Examine prolactin's effect on SSc immune cells.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA).
  • Indirect immunofluorescence.
  • Study included 52 SSc patients and 52 controls.

Main Results:

  • Significantly higher prolactin levels in SSc patients (male and female).
  • SSc lymphocytes produced more prolactin than controls.

Related Experiment Videos

  • Prolactin receptors were equally present on SSc and control lymphocytes.
  • Prolactin stimulation increased soluble interleukin 2 receptor (CD25) in lymphocytes.

    • Conclusions:

    • Lymphocytes may contribute to high prolactin levels in SSc.
    • SSc lymphocytes are sensitive to prolactin stimulation.
    • Pharmacological reduction of prolactin could be beneficial for SSc patients.