Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cell plasticity and tumour formation.

Malcolm R Alison1, Matthew J Lovell, Natalie C Direkze

  • 1Centre for Diabetes and Metabolic Medicine, Queen Mary' School of Medicine and Dentistry, Institute of Cell and Molecular Science, 4 Newark Street, Whitechapel, London E1 2AT, UK. m.alison@qmul.ac.uk

European Journal of Cancer (Oxford, England : 1990)
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer.

Cancer discovery·2026
Same author

Correction: Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.

Journal of neuroinflammation·2025
Same author

Central cytometabolic functional vascular coupling in health and disease.

npj metabolic health and disease·2025
Same author

Complications after complex device implantation: how important is implanter seniority?

Open heart·2025
Same author

Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.

Journal of neuroinflammation·2025
Same journal

Early-onset colorectal cancer across Europe: Burden, mechanisms, and health-system implications.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Clinical urgency of incidental findings in the first year of the 4-IN-THE-LUNG-RUN lung cancer screening program.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Clinically relevant endpoints and quality-of-life outcomes with darolutamide in patients with metastatic hormone-sensitive prostate cancer: Analyses of the phase III ARASENS trial.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Mapping the anatomical landscape of colorectal tumours: Location-specific efficacy of anti-epidermal growth factor receptor antibodies: Pooled analysis of randomised trials.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Left behind but not left alone: Excluded cell populations in the non-small cell lung cancer stroma predict superior long-term overall survival.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Survival outcomes of adjuvant therapy in resected stage III melanoma: Results from a real-life cohort study (TAMARIS).

European journal of cancer (Oxford, England : 1990)·2026
See all related articles

Stem cell plasticity allows bone marrow cells (BMCs) to regenerate damaged tissues. These cells may also play a role in tumor development and progression, impacting cancer therapy.

Area of Science:

  • * Regenerative Medicine and Stem Cell Biology
  • * Oncology and Cancer Biology

Background:

  • * Stem cell plasticity is the capacity of stem cells to differentiate into various cell types, including unexpected lineages.
  • * Bone marrow cells (BMCs) demonstrate plasticity, contributing to the repair of non-hematopoietic tissues.
  • * The mechanisms of BMC contribution to tissue regeneration are multifaceted, involving direct differentiation, cell fusion, paracrine signaling, and neovascularization.

Purpose of the Study:

  • * To review the concept of stem cell plasticity with a focus on bone marrow cells (BMCs).
  • * To explore the implications of BMC plasticity in tissue regeneration and its potential roles in oncology.
  • * To discuss the therapeutic relevance of BMCs in non-hematopoietic tissue repair and cancer biology.

Main Methods:

Related Experiment Videos

  • * Comprehensive literature review of studies on stem cell plasticity, focusing on bone marrow cells.
  • * Analysis of evidence for BMC contribution to tissue regeneration in various non-hematopoietic organs.
  • * Examination of the role of BMCs in tumor stroma and vasculature formation, and potential BMC-derived tumors.

Main Results:

  • * Bone marrow cells (BMCs) exhibit plasticity, contributing to the regeneration of damaged non-hematopoietic tissues.
  • * Potential mechanisms include BMCs differentiating into parenchymal cells, fusing with existing cells, providing growth factors, or promoting neovascularization.
  • * BMCs can contribute to tumor stroma and vasculature, with evidence suggesting some carcinomas may originate from BMCs.

Conclusions:

  • * Stem cell plasticity, particularly in BMCs, offers significant potential for tissue regeneration strategies.
  • * The role of BMCs in cancer, including tumor stroma and vasculature development, has critical implications for cancer biology and therapy.
  • * Further research into BMC plasticity is warranted to fully elucidate their therapeutic applications and oncogenic potential.