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Updated: Aug 9, 2026

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
Published on: May 14, 2018
Life-threatening adverse drug reaction to paclitaxel. Postmarketing surveillance
A Ruiz-Casado1, J Calzas, J García
1Medical Oncology Department, Hospital de Fuenlabrada, Madrid, Spain. aruiz.hflr@salud.madrid.org
Abstract:
The mechanism of action of hypersensitivity reactions from paclitaxel has not been fully understood. It has not even been defined if they are secondary to paclitaxel, its vehicle or the premedication. Postmarketing pharmacovigilance is predominantly based on spontaneous reporting. These reports albeit biased and incomplete serve to detect previously unrecognised adverse events. We report a life threatening adverse event related to paclitaxel without any evidence of histamine release. It consisted of a cardiac arrest probably secondary to bradiarrhythmia or branch block.
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