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Related Experiment Videos

Effect of processing variables on micro particulate system of aceclofenac.

Kamlesh Dashora1, S Saraf, Swarnlata Saraf

  • 1Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492 010, India.

Pakistan Journal of Pharmaceutical Sciences
|April 25, 2006
PubMed
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This study optimized microparticulate systems of aceclofenac using cellulose acetate, achieving ideal particle size and high drug entrapment. The developed microparticles offer prolonged drug release over 12 hours compared to conventional tablets.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Aceclofenac is a widely used non-steroidal anti-inflammatory drug (NSAID).
  • Conventional dosage forms of aceclofenac have limitations in sustained drug delivery.
  • Microparticulate systems offer potential for controlled and prolonged drug release.

Purpose of the Study:

  • To prepare and characterize microparticulate systems of aceclofenac using a modified solvent evaporation method.
  • To investigate the effects of polymer-drug ratio, agitation speed, and stirring time on microparticle properties.
  • To evaluate the in-vitro drug release profile of the optimized microparticulate system.

Main Methods:

  • Modified solvent evaporation technique was employed for microparticle preparation.
  • Cellulose acetate was used as the polymer, with varying polymer:drug ratios (1:9 to 1:1).

Related Experiment Videos

  • Processing parameters including agitation speed (500-1500 rpm) and stirring time (5-15 min) were optimized.
  • Microparticle size, entrapment efficiency, angle of repose, compressibility index, and in-vitro drug release were evaluated.

    • Main Results:

    • Microparticle size increased with higher polymer concentration but decreased with increased agitation speed and stirring time.
    • Optimal microparticle characteristics (size uniformity, angle of repose, compressibility index) were achieved at a 1:6 polymer:drug ratio, 1000 rpm, and 10 min stirring time.
    • The optimized microparticulate system demonstrated sustained in-vitro drug release exceeding 12 hours.
    • All formulations followed first-order release kinetics, indicating diffusion-controlled drug release.

    Conclusions:

    • The modified solvent evaporation method is effective for preparing aceclofenac microparticulate systems.
    • Optimized processing parameters significantly influence microparticle characteristics and drug release.
    • The developed microparticulate system provides a promising approach for prolonged aceclofenac delivery, enhancing therapeutic efficacy and patient compliance.