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Obesity: an independent risk factor for systemic oxidative stress.

Nazish Iqbal Khan1, Lubna Naz, Ghazala Yasmeen

  • 1Department of Physiology, University of Karachi, Karachi-75270, Pakistan. nazish_iqbal_khan@yahoo.com

Pakistan Journal of Pharmaceutical Sciences
|April 25, 2006
PubMed
Summary

Obesity is linked to lower levels of protective antioxidants in the body, increasing oxidative stress. This occurs even without other health complications, highlighting obesity as an independent risk factor.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Obesity is a known risk factor for various chronic diseases including diabetes, hyperlipidemia, and cardiovascular conditions.
  • Emerging research suggests a potential link between obesity and altered antioxidant activity.
  • The independent role of obesity in oxidative stress requires further investigation.

Purpose of the Study:

  • To investigate the hypothesis that obesity independently contributes to reduced cytoprotective antioxidant activity in humans.
  • To assess the association between body mass index (BMI) and erythrocyte glutathione (GSH) concentrations.
  • To determine if obesity enhances systemic oxidative stress in the absence of other comorbidities.

Main Methods:

  • Cross-sectional study involving 150 age-matched female subjects.

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  • Participants were categorized into different grades of obesity based on BMI.
  • Measurements included hemoglobin and erythrocyte glutathione (GSH) concentrations.

    • Main Results:

    • A significant negative correlation was observed between increased BMI and erythrocyte glutathione (GSH) concentration.
    • Higher BMI was associated with decreased levels of this key antioxidant.
    • These findings suggest a direct impact of obesity on antioxidant defenses.

    Conclusions:

    • Obesity, independent of comorbidities like diabetes or hyperlipidemia, can diminish the body's antioxidant defenses.
    • Increased systemic oxidative stress is a consequence of obesity.
    • Obesity warrants significant clinical attention due to its role in reducing antioxidant activity and promoting oxidative stress.