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Related Experiment Videos

Sonic hedgehog signaling is important in tooth root development.

M Nakatomi1, I Morita, K Eto

  • 1Section of Molecular Craniofacial Embryology, Tokyo Medical and Dental University, Japan.

Journal of Dental Research
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

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Sonic hedgehog (Shh) signaling is crucial for tooth root development. This pathway regulates Hertwig's epithelial root sheath (HERS) function, impacting molar eruption and root length in mice.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Dental Research

Background:

  • Hertwig's epithelial root sheath (HERS) plays a vital role in tooth root formation.
  • The precise molecular mechanisms governing root development signaling are not fully understood.

Purpose of the Study:

  • To investigate the role of Sonic hedgehog (Shh) signaling in Hertwig's epithelial root sheath (HERS) function during tooth root development.
  • To elucidate the molecular basis of root development signaling pathways.

Main Methods:

  • Examined gene expression patterns of Shh signaling components (Shh, Patched1, Patched2, Smoothened, Gli1) in murine developing molar roots.
  • Utilized mesenchymal dysplasia (mes) mice with a mutated PATCHED1 protein to assess in vivo Shh signaling function.
  • Analyzed cell proliferation using markers like BrdU and PCNA, and observed molar eruption and root length.

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Main Results:

  • Shh and Patched2 transcripts were detected in the HERS.
  • Patched1, Smoothened, and Gli1 were expressed in both HERS and dental mesenchyme.
  • In Shh signaling-deficient mice (mes mice), cell proliferation around HERS was reduced, molar eruption was disturbed, and roots were significantly shorter.

Conclusions:

  • Sonic hedgehog (Shh) signaling is essential for normal tooth root development.
  • Shh signaling regulates cell proliferation and influences molar eruption and root elongation.