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[Chemotherapy in rectal cancer].

Joong Bae Ahn1

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. vvswm513@yumc.yonsei.ac.kr

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|April 25, 2006
PubMed
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Colorectal cancer treatment has advanced with new drugs like oxaliplatin and biologic agents, improving patient survival and quality of life. Ongoing research explores novel therapies for advanced and adjuvant settings.

Area of Science:

  • Oncology
  • Medical Chemistry

Context:

  • Colorectal cancer treatment was limited to fluorouracil until the mid-1990s.
  • Significant advancements have occurred in the last decade for advanced colorectal cancer therapy.

Purpose:

  • To review the evolution of colorectal cancer treatment, including chemotherapy and biologic agents.
  • To highlight the impact of new therapeutic strategies on patient outcomes.

Summary:

  • Oxaliplatin and irinotecan, combined with fluoropyrimidines, have improved survival and quality of life in advanced colorectal cancer.
  • Oral fluoropyrimidines offer an alternative administration route for combination therapy.
  • Biologic agents (cetuximab, bevacizumab) integrated with chemotherapy have expanded treatment options and spurred targeted therapy research.

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Impact:

  • Improved survival and quality of life for patients with advanced colorectal cancer.
  • Development of targeted therapies represents a promising area in colorectal cancer research.
  • Ongoing trials are evaluating new agents in adjuvant and chemoradiation settings for colon and rectal cancers.