[TNM staging, molecular staging and prognostic factors of rectal cancer]

Pathologic evaluation of the resected specimen is a critical component when managing the patients with rectal cancer, from initial diagnosis through definitive treatment. The best estimation of prognosis in rectal cancer is related to the anatomic extent of disease determined by pathology. Although a large number of staging system has been developed for rectal cancer over the years, use of TNM staging system of the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer) are gaining popularity among the colorectal surgeons. Multiple genetic alterations are the prerequisite for carcinogenesis including rectal cancer. Although numerous molecular markers are investigated in relation to prognosis or response to therapy of rectal cancer, those molecular markers could not provide sufficient evidence for the incorporation of available prognostic biomarkers into clinical practice. In this article, the evolution of staging system of rectal cancer and its prognostic relevance are reviewed comprehensively.