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Updated: Aug 9, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Distraction osteogenesis in a patient with juvenile arthritis
Richard L Mackool1, Pradip Shetye, Barry Grayson
1The Institute of Reconstructive Plastic Surgery, New York, New York.
Abstract:
We present a 26-year-old patient with juvenile-onset arthritis, Alagille's syndrome, micrognathia, and progressive sleep apnea. Despite the presence of significant temporomandibular joint pathology, mandibular distraction was indicated to correct life-threatening sleep apnea. Before distraction, the patient had only 10 mm of maximal interincisal opening and bilateral temporomandibular joint symptomatology. After distraction, the patient's sleep apnea resolved. There was slight improvement in her maximal incisal opening (12 mm) with neither exacerbation nor improvement of her temporomandibular joint symptomatology.
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