Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene-environment interactions in mental disorders.

Ming T Tsuang1, Jessica L Bar, William S Stone

  • 1Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA.

World Psychiatry : Official Journal of the World Psychiatric Association (WPA)
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.

The American journal of psychiatry·2026
Same author

Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts.

Nature. Mental health·2026
Same author

Tobacco Use is Related to Parietal-Hippocampal Connectivity in People at Clinical High Risk for Psychosis.

medRxiv : the preprint server for health sciences·2026
Same author

Investigating Pathway-Partitioned Polygenic Risk Scores for Schizophrenia: Insights into Clinical Variability in Two Patient Cohorts.

medRxiv : the preprint server for health sciences·2026
Same author

Cannabis and Tobacco Co-Use Is Associated With Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Longitudinal Relationships Between Cannabis and Tobacco Use and Symptom Severity in Individuals at Clinical High Risk for Psychosis.

medRxiv : the preprint server for health sciences·2026
Same journal

Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same journal

Artificial intelligence and the problem of physician burnout: a double-edged scalpel.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same journal

The neurodiversity movement vs. the medical model of autism.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same journal

The burnout paradox.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same journal

Interventions in schizophrenia should be transdiagnostic, biologically informed, individualized, and disease modifying.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same journal

Predicting long-term poor outcomes in individuals at clinical high risk for psychosis using real-world clinical data: the OASIS1000 prospective study.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
See all related articles

Gene-environment interactions significantly influence mental disorders. Understanding how genetic sensitivity shapes responses to environmental factors is crucial for comprehending psychopathology development.

Area of Science:

  • Psychiatry and Genetics
  • Neurodevelopmental Disorders

Background:

  • Both genetic (nature) and environmental (nurture) factors contribute to psychopathology.
  • Gene-environment interaction is defined as genetic control of sensitivity to environmental influences.

Purpose of the Study:

  • To examine methodological challenges in studying gene-environment interactions.
  • To review evidence for gene-environment interactions in psychiatric and neurodevelopmental disorders.

Main Methods:

  • Review of existing literature on gene-environment interactions.
  • Analysis of data from twin, adoption, and association studies.
  • Focus on specific neurodevelopmental conditions like autism and schizophrenia.

Main Results:

Related Experiment Videos

  • Methodological issues in gene-environment interaction research are discussed.
  • Evidence supports the role of gene-environment interactions in various psychiatric conditions.
  • Gene-environment interactions are implicated in autism and schizophrenia.

Conclusions:

  • Gene-environment interactions are a key factor in the etiology of mental disorders.
  • Further research is needed to elucidate these complex interactions in conditions such as autism and schizophrenia.