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Susceptibility to murine hepatitis virus (type 3)-induced paralysis is influenced by class I genes of the MHC
D Oth1, G Lussier, V C Cainelli-Gebara
1Centre de Recherche en Immunologie, Institut Armand-Frappier, Laval-des-Rapides, Québec, Canada.
Abstract:
Using H-2 recombinant congenic strains of mice, genetic analysis of resistance to murine hepatitis virus type 3 (MHV3)-induced paralysis was performed. It appeared that both H-2K and H-2D, two class I gene regions of the mouse major histocompatibility complex (MHC), can play independent significant roles in the establishment of such resistance.