Growth factor regulation of adrenal cortex growth and function

The control of adrenal cortex growth in vivo during development or under certain stress conditions is still very poorly understood at the molecular level. Some information can be collected however from in vitro experiments. Acidic and basic FGF appear to be the most potent mitogens, so far, for primary cultures of adult adrenocortical cells, whereas EGF can also stimulate growth of fetal cells. Several growth factors have emerged in the recent years as multifunctional molecules that play important regulatory functions on adrenocortical steroidogenesis. These include EGF, IL-1, insulin, IGF-1 and TGF beta. In certain cases (e.g. IGF-1, TGF beta), these factors participate in autocrine loops of regulation. The differential expression, release and activation of these factors might locally regulate the steroidogenic action of the hormonal signals delivered through the hypothalamo-pituitary-adrenal axis.