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Oxidative stress and enzymic-non-enzymic antioxidant responses in children with acute pneumonia

Mustafa Cemek1, Hüseyin Caksen, Fahri Bayiroğlu

  • 1Department of Chemistry (Biochemistry Division), Faculty of Science, Afyon Kocatepe University, Afyon, Turkey. mcemek@yahoo.com

Cell Biochemistry and Function
|April 25, 2006
PubMed

Insights

Children with acute pneumonia exhibit increased oxidative stress and significantly lower levels of both enzymic and non-enzymic antioxidants. This study highlights a critical imbalance in antioxidant status during pediatric pneumonia.

Area of Science:

  • Pediatric Medicine
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Acute pneumonia in children is a significant health concern.
  • Oxidative stress plays a role in various inflammatory conditions.
  • Understanding antioxidant status is crucial for managing pediatric diseases.

Purpose of the Study:

  • To investigate oxidative stress markers.
  • To assess the status of enzymic and non-enzymic antioxidants in children with acute pneumonia.
  • To compare these markers between children with pneumonia and healthy controls.

Main Methods:

  • Studied 28 children with acute pneumonia and 29 controls (ages 2-12).
  • Measured whole blood malondialdehyde (MDA) and reduced glutathione (GSH).
  • Assessed serum levels of beta-carotene, retinol, vitamin C, vitamin E, catalase (CAT), ceruloplasmin (CLP), total bilirubin, erythrocyte superoxide dismutase (SOD), and glutathione peroxidase (GPx).

Main Results:

  • Children with pneumonia showed higher MDA, CLP, and total bilirubin levels.
  • Significantly lower levels of SOD, GPx, beta-carotene, retinol, vitamin C, vitamin E, and GSH were observed in the pneumonia group.
  • Serum CAT levels did not show a statistically significant difference between groups.

Conclusions:

  • Acute pneumonia in children is associated with elevated oxidative stress.
  • Enzymic and non-enzymic antioxidant activities are significantly reduced in pediatric acute pneumonia.
  • These findings suggest a compromised antioxidant defense system in children suffering from acute pneumonia.

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