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Updated: Aug 9, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Emerging therapies for the treatment and prevention of otitis media
Avner Aliphas1, Neil Prufer, Kenneth M Grundfast
1Boston Medical Center, Department of Otolaryngology--Head & Neck Surgery, 88 East Newton Street, D616 Boston, MA 02118, USA. avners@bu.edu
Abstract:
Otitis media is one of the most common disorders occurring in children, and there is growing concern that bacteria are quickly becoming resistant to antimicrobials. As a result, global antibiotic treatment is no longer the standard of care and treatment of otitis media has changed dramatically in the last decade. In addition to new antimicrobials currently in development, the effects of the pneumococcal conjugate vaccine are just beginning to be understood. Furthermore, new surgical techniques are for the first time being tested as alternatives for tympanostomy tubes for recurrent acute otitis media. This review discusses current and emerging otitis media therapeutics, with particular attention to acute otitis media. Topics include antimicrobial use, antimicrobial resistance, effects of vaccination and new surgical techniques.
Insights
Emerging antimicrobial resistance in otitis media necessitates new treatments. This review covers evolving therapeutics, including vaccines and surgical options, for childhood ear infections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Otolaryngology
Background:
- Otitis media is a common childhood illness.
- Increasing antimicrobial resistance is a significant concern.
- Traditional antibiotic treatments are becoming less effective.
Purpose of the Study:
- To review current and emerging therapeutics for otitis media.
- To focus on acute otitis media treatments.
- To discuss antimicrobial use, resistance, vaccination, and surgical techniques.
Main Methods:
- Literature review of current otitis media therapeutics.
- Analysis of antimicrobial resistance trends.
- Evaluation of vaccine efficacy and new surgical techniques.
Main Results:
- Antimicrobial resistance is altering otitis media treatment protocols.
- Pneumococcal conjugate vaccine impact is under investigation.
- Novel surgical alternatives to tympanostomy tubes are being explored.
Conclusions:
- Treatment for otitis media is evolving due to resistance.
- Vaccination and new surgical methods offer promising alternatives.
- Continued research into novel therapeutics is crucial.
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