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HLA Cw*06 is not essential for streptococcal-induced psoriasis
L Fry1, A V Powles, S Corcoran
1Faculty of Medicine, Imperial College, London, UK, and The Skin Hospital, Dublin 2, Ireland.
The British Journal of Dermatology
|April 26, 2006
Summary
Psoriasis patients, particularly those with guttate flares, show a higher prevalence of Human Leukocyte Antigen Cw6 (HLA Cw6) and streptococcal infections. However, not all patients with streptococcal-related psoriasis carry the HLA Cw6 genotype.
Area of Science:
- Immunodermatology
- Genetics
- Microbiology
Background:
- Streptococcal infections and HLA Cw6 are linked to psoriasis pathogenesis, especially the guttate form.
- This study investigates the association in Irish patients.
Purpose of the Study:
- To examine the relationship between streptococcal infections and HLA Cw6 (Cw*06) in 105 Irish psoriasis patients.
- To compare these factors between guttate and chronic plaque psoriasis subtypes.
Main Methods:
- Patients were categorized into guttate psoriasis (GG, n=64) and chronic plaque psoriasis (CPG, n=41) groups.
- Prevalence of HLA Cw*06 and evidence of streptococcal infection were assessed in both groups.
Main Results:
- HLA Cw*06 incidence was high in both GG (86%) and CPG (73%), significantly exceeding controls (18%).
- Evidence of streptococcal infection was more frequent in the GG (56%) than CPG (32%).
- Among patients with streptococcal infection, a high percentage in both GG (83%) and CPG (69%) carried the Cw*06 genotype.
Conclusions:
- The findings suggest that while HLA Cw*06 and streptococcal infections are associated with psoriasis, not all affected individuals possess the Cw*06 genotype.
- The precise role of HLA Cw*06 in streptococcal-related psoriasis requires further investigation.