Related Experiment Video
Updated: Aug 9, 2026
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Morphine-associated pruritus after single extradural administration in a horse
John H Burford1, Kevin T T Corley
1Department of Veterinary Clinical Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, UK.
Abstract:
Pruritus following a single administration of 100 microg kg(-1) of preservative-free morphine sulphate given via an extradural catheter was seen in a 580 kg horse. The catheter was placed in the first intercoccygeal space. Focal irritation, represented by both local alopecia over the left gluteal muscles and serum exudation, occurred 4-8 hours after injection. This was attributed to the extradural morphine administration.
